Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections.
Identifieur interne : 000002 ( Main/Exploration ); précédent : 000001; suivant : 000003Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections.
Auteurs : Simone A. Thair [États-Unis] ; Yudong D. He [États-Unis] ; Yehudit Hasin-Brumshtein [États-Unis] ; Suraj Sakaram [États-Unis] ; Rushika Pandya [États-Unis] ; Jiaying Toh [États-Unis] ; David Rawling [États-Unis] ; Melissa Remmel [États-Unis] ; Sabrina Coyle [États-Unis] ; George N. Dalekos [Grèce] ; Ioannis Koutsodimitropoulos [Grèce] ; Glykeria Vlachogianni [Grèce] ; Eleni Gkeka [Grèce] ; Eleni Karakike [Grèce] ; Georgia Damoraki [Grèce] ; Nikolaos Antonakos [Grèce] ; Purvesh Khatri [États-Unis] ; Evangelos J. Giamarellos-Bourboulis [Grèce] ; Timothy E. Sweeney [États-Unis]Source :
- iScience [ 2589-0042 ] ; 2021.
Abstract
The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56bright natural killer cells and M2 macrophages. The concordant and discordant responses mapped out here provide a window to explore the pathophysiology of the host response to SARS-CoV-2.
DOI: 10.1016/j.isci.2020.101947
PubMed: 33437935
PubMed Central: PMC7786129
Affiliations:
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Dalekos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University of Thessaly, Larissa General Hospital, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Internal Medicine, University of Thessaly, Larissa General Hospital</wicri:regionArea><wicri:noRegion>Larissa General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Koutsodimitropoulos, Ioannis" sort="Koutsodimitropoulos, Ioannis" uniqKey="Koutsodimitropoulos I" first="Ioannis" last="Koutsodimitropoulos">Ioannis Koutsodimitropoulos</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Latseion General Hospital of Elefsis, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Intensive Care Unit, Latseion General Hospital of Elefsis</wicri:regionArea><wicri:noRegion>Latseion General Hospital of Elefsis</wicri:noRegion></affiliation></author><author><name sortKey="Vlachogianni, 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Medicine, Stanford University, Palo Alto, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Giamarellos Bourboulis, Evangelos J" sort="Giamarellos Bourboulis, Evangelos J" uniqKey="Giamarellos Bourboulis E" first="Evangelos J" last="Giamarellos-Bourboulis">Evangelos J. 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Thair</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="He, Yudong D" sort="He, Yudong D" uniqKey="He Y" first="Yudong D" last="He">Yudong D. He</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hasin Brumshtein, Yehudit" sort="Hasin Brumshtein, Yehudit" uniqKey="Hasin Brumshtein Y" first="Yehudit" last="Hasin-Brumshtein">Yehudit Hasin-Brumshtein</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sakaram, Suraj" sort="Sakaram, Suraj" uniqKey="Sakaram S" first="Suraj" last="Sakaram">Suraj Sakaram</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pandya, Rushika" sort="Pandya, Rushika" uniqKey="Pandya R" first="Rushika" last="Pandya">Rushika Pandya</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Toh, Jiaying" sort="Toh, Jiaying" uniqKey="Toh J" first="Jiaying" last="Toh">Jiaying Toh</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rawling, David" sort="Rawling, David" uniqKey="Rawling D" first="David" last="Rawling">David Rawling</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Remmel, Melissa" sort="Remmel, Melissa" uniqKey="Remmel M" first="Melissa" last="Remmel">Melissa Remmel</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Coyle, Sabrina" sort="Coyle, Sabrina" uniqKey="Coyle S" first="Sabrina" last="Coyle">Sabrina Coyle</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dalekos, George N" sort="Dalekos, George N" uniqKey="Dalekos G" first="George N" last="Dalekos">George N. Dalekos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University of Thessaly, Larissa General Hospital, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Internal Medicine, University of Thessaly, Larissa General Hospital</wicri:regionArea><wicri:noRegion>Larissa General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Koutsodimitropoulos, Ioannis" sort="Koutsodimitropoulos, Ioannis" uniqKey="Koutsodimitropoulos I" first="Ioannis" last="Koutsodimitropoulos">Ioannis Koutsodimitropoulos</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Latseion General Hospital of Elefsis, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Intensive Care Unit, Latseion General Hospital of Elefsis</wicri:regionArea><wicri:noRegion>Latseion General Hospital of Elefsis</wicri:noRegion></affiliation></author><author><name sortKey="Vlachogianni, Glykeria" sort="Vlachogianni, Glykeria" uniqKey="Vlachogianni G" first="Glykeria" last="Vlachogianni">Glykeria Vlachogianni</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Aghios Dimitrios Thessaloniki General Hospital, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Intensive Care Unit, Aghios Dimitrios Thessaloniki General Hospital</wicri:regionArea><wicri:noRegion>Aghios Dimitrios Thessaloniki General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Gkeka, Eleni" sort="Gkeka, Eleni" uniqKey="Gkeka E" first="Eleni" last="Gkeka">Eleni Gkeka</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, AHEPA Thessaloniki General Hospital, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Intensive Care Unit, AHEPA Thessaloniki General Hospital</wicri:regionArea><wicri:noRegion>AHEPA Thessaloniki General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Karakike, Eleni" sort="Karakike, Eleni" uniqKey="Karakike E" first="Eleni" last="Karakike">Eleni Karakike</name><affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Damoraki, Georgia" sort="Damoraki, Georgia" uniqKey="Damoraki G" first="Georgia" last="Damoraki">Georgia Damoraki</name><affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Antonakos, Nikolaos" sort="Antonakos, Nikolaos" uniqKey="Antonakos N" first="Nikolaos" last="Antonakos">Nikolaos Antonakos</name><affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Khatri, Purvesh" sort="Khatri, Purvesh" uniqKey="Khatri P" first="Purvesh" last="Khatri">Purvesh Khatri</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Giamarellos Bourboulis, Evangelos J" sort="Giamarellos Bourboulis, Evangelos J" uniqKey="Giamarellos Bourboulis E" first="Evangelos J" last="Giamarellos-Bourboulis">Evangelos J. Giamarellos-Bourboulis</name><affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens</wicri:regionArea><wicri:noRegion>124 62 Athens</wicri:noRegion></affiliation></author><author><name sortKey="Sweeney, Timothy E" sort="Sweeney, Timothy E" uniqKey="Sweeney T" first="Timothy E" last="Sweeney">Timothy E. Sweeney</name><affiliation wicri:level="2"><nlm:affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">iScience</title><idno type="eISSN">2589-0042</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56<sup>bright</sup> natural killer cells and M2 macrophages. The concordant and discordant responses mapped out here provide a window to explore the pathophysiology of the host response to SARS-CoV-2.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33437935</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>14</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2589-0042</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>Jan</Month><Day>22</Day></PubDate></JournalIssue><Title>iScience</Title><ISOAbbreviation>iScience</ISOAbbreviation></Journal><ArticleTitle>Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections.</ArticleTitle><Pagination><MedlinePgn>101947</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.isci.2020.101947</ELocationID><Abstract><AbstractText>The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56<sup>bright</sup> natural killer cells and M2 macrophages. The concordant and discordant responses mapped out here provide a window to explore the pathophysiology of the host response to SARS-CoV-2.</AbstractText><CopyrightInformation>© 2020 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thair</LastName><ForeName>Simone A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Yudong D</ForeName><Initials>YD</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasin-Brumshtein</LastName><ForeName>Yehudit</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakaram</LastName><ForeName>Suraj</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pandya</LastName><ForeName>Rushika</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toh</LastName><ForeName>Jiaying</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rawling</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Remmel</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coyle</LastName><ForeName>Sabrina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalekos</LastName><ForeName>George N</ForeName><Initials>GN</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Thessaly, Larissa General Hospital, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koutsodimitropoulos</LastName><ForeName>Ioannis</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Latseion General Hospital of Elefsis, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vlachogianni</LastName><ForeName>Glykeria</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Aghios Dimitrios Thessaloniki General Hospital, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gkeka</LastName><ForeName>Eleni</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, AHEPA Thessaloniki General Hospital, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karakike</LastName><ForeName>Eleni</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Damoraki</LastName><ForeName>Georgia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonakos</LastName><ForeName>Nikolaos</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khatri</LastName><ForeName>Purvesh</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giamarellos-Bourboulis</LastName><ForeName>Evangelos J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sweeney</LastName><ForeName>Timothy E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Inflammatix, Inc., 863 Mitten Road, Suite 104, Burlingame, CA 94010, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>iScience</MedlineTA><NlmUniqueID>101724038</NlmUniqueID><ISSNLinking>2589-0042</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Immunology: Bioinformatics</Keyword><Keyword MajorTopicYN="N">Molecular Biology</Keyword><Keyword MajorTopicYN="N">Transcriptomics</Keyword></KeywordList><CoiStatement>S.A.T., Y.D.H., Y.H., S.S., R.P., D.R., M.R., S.C., and T.E.S. are employees of and stockholders in Inflammatix, Inc. P.K. reports being a shareholder and a consultant to Inflammatix, Inc. E.J.G.B. reports receiving honoraria from 10.13039/100006483AbbVie 10.13039/100011408USA, Abbott CH, InflaRx GmbH, MSD Greece, XBiotech Inc., and 10.13039/501100006546Angelini Italy; independent educational grants from 10.13039/100006483AbbVie, Abbott, 10.13039/501100006044Astellas Pharma Europe, AxisShield, bioMérieux Inc, InflaRx GmbH, and XBiotech Inc; and funding from the FrameWork 7 program HemoSpec (granted to the National and Kapodistrian University of Athens), the 10.13039/501100007601Horizon 2020 Marie-Curie Project European Sepsis Academy (granted to the National and Kapodistrian University of Athens), and the 10.13039/501100007601Horizon 2020 European Grant ImmunoSep (granted to the Hellenic Institute for the Study of Sepsis). The other authors declare no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>14</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33437935</ArticleId><ArticleId IdType="doi">10.1016/j.isci.2020.101947</ArticleId><ArticleId 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He</name><name sortKey="Khatri, Purvesh" sort="Khatri, Purvesh" uniqKey="Khatri P" first="Purvesh" last="Khatri">Purvesh Khatri</name><name sortKey="Khatri, Purvesh" sort="Khatri, Purvesh" uniqKey="Khatri P" first="Purvesh" last="Khatri">Purvesh Khatri</name><name sortKey="Pandya, Rushika" sort="Pandya, Rushika" uniqKey="Pandya R" first="Rushika" last="Pandya">Rushika Pandya</name><name sortKey="Rawling, David" sort="Rawling, David" uniqKey="Rawling D" first="David" last="Rawling">David Rawling</name><name sortKey="Remmel, Melissa" sort="Remmel, Melissa" uniqKey="Remmel M" first="Melissa" last="Remmel">Melissa Remmel</name><name sortKey="Sakaram, Suraj" sort="Sakaram, Suraj" uniqKey="Sakaram S" first="Suraj" last="Sakaram">Suraj Sakaram</name><name sortKey="Sweeney, Timothy E" sort="Sweeney, Timothy E" uniqKey="Sweeney T" first="Timothy E" last="Sweeney">Timothy E. Sweeney</name><name sortKey="Toh, Jiaying" sort="Toh, Jiaying" uniqKey="Toh J" first="Jiaying" last="Toh">Jiaying Toh</name><name sortKey="Toh, Jiaying" sort="Toh, Jiaying" uniqKey="Toh J" first="Jiaying" last="Toh">Jiaying Toh</name></country><country name="Grèce"><noRegion><name sortKey="Dalekos, George N" sort="Dalekos, George N" uniqKey="Dalekos G" first="George N" last="Dalekos">George N. Dalekos</name></noRegion><name sortKey="Antonakos, Nikolaos" sort="Antonakos, Nikolaos" uniqKey="Antonakos N" first="Nikolaos" last="Antonakos">Nikolaos Antonakos</name><name sortKey="Damoraki, Georgia" sort="Damoraki, Georgia" uniqKey="Damoraki G" first="Georgia" last="Damoraki">Georgia Damoraki</name><name sortKey="Giamarellos Bourboulis, Evangelos J" sort="Giamarellos Bourboulis, Evangelos J" uniqKey="Giamarellos Bourboulis E" first="Evangelos J" last="Giamarellos-Bourboulis">Evangelos J. Giamarellos-Bourboulis</name><name sortKey="Gkeka, Eleni" sort="Gkeka, Eleni" uniqKey="Gkeka E" first="Eleni" last="Gkeka">Eleni Gkeka</name><name sortKey="Karakike, Eleni" sort="Karakike, Eleni" uniqKey="Karakike E" first="Eleni" last="Karakike">Eleni Karakike</name><name sortKey="Koutsodimitropoulos, Ioannis" sort="Koutsodimitropoulos, Ioannis" uniqKey="Koutsodimitropoulos I" first="Ioannis" last="Koutsodimitropoulos">Ioannis Koutsodimitropoulos</name><name sortKey="Vlachogianni, Glykeria" sort="Vlachogianni, Glykeria" uniqKey="Vlachogianni G" first="Glykeria" last="Vlachogianni">Glykeria Vlachogianni</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
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|clé= pubmed:33437935
|texte= Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections.
}}
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